at Computational Cancer Genomics Group, CNIO, Madrid
The Computational Cancer Genomics Group at the Spanish National Cancer Research Center (CNIO) invites applications for a postdoctoral position focused on investigating the molecular bases and therapeutic implications of cellular heterogeneity in pancreatic cancer. CNIO, a premier cancer research institution in Spain, offers a dynamic environment that spans fundamental biology to clinical cancer research. Under the leadership of Dr. Solip Park, our lab is dedicated to understanding the context- specific cancer fitness landscape by analyzing both inherited and somatic alterations (Song et al., 2023, Genome Medicine; Park et al., 2021, Nature Communications).
This project involves systematic and rigorous statistical analysis of extensive sequencing data from cancer patients. Key aims include:
Identifying novel cancer predisposition genes for hereditary cancer patients using AI and machine learning approaches. Developing AI-based structural simulations to explore position-specific protein interaction dynamics. Discovering early-onset cancer factors through innovative omics approaches.
Our goal is to advance understanding of comprehensive genomic alterations to improve cancer classification and risk assessment, ultimately enhancing prevention strategies.
Responsibilities: Lead a project to understand age-associated cancer progression with international collaborators, identifying novel mechanisms of cancer initiation. Develop an AI-based model to decipher context-specific protein interaction perturbations.
Manage large-scale, heterogeneous data collection and process various datasets from cancer patients. Develop and refine computational models by analyzing multi-omics datasets. Supervise master’s and Ph.D. students, providing technical expertise to both the lab and collaborators. Collaborate with research teams for data acquisition and troubleshooting.
Selection criteria: Ph.D. in biology, bioinformatics, systems biology, computational biology, computer/data science, structural biology, or related fields. Extensive experience in big data analysis, including cancer genomics, network biology, structural modeling, and computational model/software development. Proficiency in computational languages (e.g., R, Python). Strong team player with excellent communication skills.
Additional information: This position offers a unique opportunity to contribute to cutting-edge cancer research with a focus on personalized medicine for four years. The role includes a competitive salary (minimum €45,000/year) and a benefits package, including an independent budget for equipment, conferences, or personal needs (€6,500/year).
How to apply?: Please send CV and a brief summary of your research to Solip Park (solippark@cnio.es). Deadline for applications: September 30, 2024